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 1b)16. It has been proposed the hetero-amyloid fashioned upstream of RIPK3 amyloid could serve as a template to recruit free RIPK3 in the same construction, thus transducing and amplifying necrotic alerts from RIPK1 to RIPK33. Nonetheless, the RIPK1/RIPK3 hetero elaborate can't induce RIPK3 kinase activation directly17, the RIPK3 self-assembly is